Oxacillin sodium salt is primarily used as an antibiotic to treat infections caused by penicillinase-producing staphylococci. It is effective in managing skin and soft tissue infections, respiratory tract infections, and bone and joint infections. In clinical settings, it is often administered intravenously or intramuscularly for severe infections, while oral formulations are available for less severe cases. It is also used prophylactically to prevent infections in patients undergoing certain surgeries. Due to its resistance to beta-lactamase enzymes, it is particularly valuable in treating infections where other penicillins might be ineffective.