Lomefloxacin hydrochloride is primarily used as an antibiotic in the treatment of various bacterial infections. It is effective against a wide range of gram-negative and gram-positive bacteria, making it suitable for treating urinary tract infections, respiratory tract infections, and skin infections. Due to its broad-spectrum activity, it is also utilized in preventing infections during surgical procedures, particularly in urology. Additionally, it is prescribed for the management of chronic bronchitis and conjunctivitis caused by susceptible bacteria. Its use is often recommended when other antibiotics are ineffective or contraindicated.