Tilmicosin is primarily used in veterinary medicine as an antibiotic to treat respiratory infections in cattle, sheep, and swine. It is effective against a range of bacterial pathogens, including Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine and porcine respiratory disease. The medication is typically administered via injection, providing a prolonged therapeutic effect, which reduces the need for frequent dosing. Oral premixes are also available for swine. Tilmicosin helps improve animal health and productivity by controlling infections that can lead to severe illness or death in livestock. It is also used in poultry to combat certain bacterial infections, though its use is more limited in this sector. Proper dosage and adherence to withdrawal periods are essential to ensure food safety and avoid antibiotic resistance.