Erythromycin A oxime is primarily used as an intermediate in the synthesis of various macrolide antibiotics. It plays a crucial role in the development of more potent and targeted antibiotics, particularly those used to treat bacterial infections that are resistant to other forms of treatment. Additionally, its derivatives are often explored for their potential in treating respiratory tract infections, skin infections, and other bacterial diseases. Researchers also investigate its applications in modifying the chemical structure of antibiotics to enhance their efficacy and reduce side effects.