Used to treat severe bacterial infections, including those in the abdomen, lungs, urinary tract, skin, and bloodstream. The combination is effective against a wide range of bacteria, especially when the infection is serious or resistant to other antibiotics. Cilastatin prevents the breakdown of Imipenem in the kidneys, increasing its effectiveness. Sodium bicarbonate is added to protect Imipenem from stomach acid when administered, ensuring better delivery and stability in the body. Commonly used in hospitalized patients with moderate to severe infections requiring intravenous antibiotic therapy.