Cloxacillin sodium salt is primarily used as an antibiotic to treat bacterial infections caused by gram-positive bacteria, especially those that are resistant to penicillin due to beta-lactamase production. It is effective in treating skin and soft tissue infections, such as boils, abscesses, and wound infections, often caused by Staphylococcus aureus. It may also be used in respiratory tract infections when staphylococcal involvement is suspected. Due to its stability against beta-lactamase enzymes, it is preferred over standard penicillin in cases where resistant strains are present. The sodium salt form enhances solubility, making it suitable for oral and injectable formulations. It is commonly prescribed in outpatient settings and is particularly valuable in managing mild to moderate infections where penicillin resistance is a concern.