Amoxicillin crystalline is widely used in the treatment of bacterial infections due to its effectiveness against a broad range of bacteria. It is commonly prescribed for respiratory tract infections such as bronchitis, pneumonia, and sinusitis. It is also effective in treating urinary tract infections, ear infections, and certain skin infections.

One of the key applications is in the management of Helicobacter pylori infections, where it is used in combination with other antibiotics and acid-suppressing agents to treat stomach ulcers. Amoxicillin crystalline is preferred in many cases because of its high oral bioavailability and favorable absorption profile when administered in crystalline form.

It is also used in dental procedures to prevent bacterial endocarditis in at-risk patients. Due to its safety and efficacy, it is frequently used in pediatric formulations for treating common childhood infections like otitis media.

The crystalline form ensures stability and consistent release, making it suitable for tablet, capsule, and suspension formulations. Its use in both outpatient and hospital settings highlights its importance in modern antibiotic therapy.