Used intravenously to treat serious bacterial infections, particularly those caused by Gram-positive pathogens resistant to other antibiotics. Effective against vancomycin-resistant Enterococcus faecium (VRE) and complicated skin and soft tissue infections. Often reserved for cases where other treatments have failed due to its use as a last-line therapy. Active against multidrug-resistant Staphylococcus aureus (MRSA) and streptococci. Its dual-component mechanism inhibits bacterial protein synthesis, reducing the likelihood of rapid resistance development. Commonly used in hospital settings for patients with limited antibiotic options.