Used primarily as an antibiotic to treat serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It is particularly effective in cases where other antibiotics have failed or are unsuitable. Often administered intravenously for severe infections such as septicemia, endocarditis, and bone and joint infections. It is also used as a prophylactic measure in patients undergoing surgery who are at high risk of developing infections. Due to its long half-life, it allows for less frequent dosing compared to other antibiotics, making it a convenient option for outpatient therapy. In some cases, it is used off-label for treating Clostridioides difficile infections when standard treatments are ineffective. Its use is carefully monitored due to the potential for side effects, including nephrotoxicity and ototoxicity.