Iclaprim is primarily used as an antibiotic to treat bacterial infections, particularly those caused by Gram-positive bacteria. It is effective against skin and skin structure infections, including complicated cases such as abscesses and wound infections. Iclaprim works by inhibiting bacterial dihydrofolate reductase, an enzyme essential for bacterial DNA synthesis, thereby stopping bacterial growth. It is often considered as an alternative for patients who are allergic to or cannot tolerate other antibiotics like sulfonamides. Its targeted action makes it a valuable option in combating resistant bacterial strains, especially in hospital settings.