Epi-DHC™ (Dihydromyricetin 5% Microemulsion, e.q. Epicelline)
Epi-DHC™ (Dihydromyricetin 5% Microemulsion, e.q. Epicelline)
Note: This product isn't manufactured by Eucerin. It only contains the same ingredient "Dihydromyricetin" as Epicelline
Extracted from: Ampelopsis grossedentata (Vine tea)
Topical Benefits of Epi-DHC™ (Dihydromyricetin)
Dihydromyricetin (DHM) is gaining attention not only for its oral health benefits but also for its potential in topical skincare applications. Recent research has explored how DHM can improve skin appearance and function. Below is an overview of its key topical benefits, supported by scientific studies.
1. Epigenetic Rejuvenation and Anti-Aging
Recent studies have identified DHM as a natural inhibitor of DNA methyltransferase (DNMT1), an enzyme involved in age-related epigenetic changes in skin cells. In cultured human keratinocytes and 3D skin models, DHM treatment has shown a moderate global hypomethylation effect, effectively “resetting” the epigenetic clock. This led to measurable reductions in the biological age of the cells, with associated benefits such as:
- Reactivation of age-silenced genes
- Increased epidermal thickness
- Predicted improvements in wrinkle grade
These findings suggest that DHM may help restore a more youthful epigenetic profile in the skin, potentially contributing to visible anti-aging effects.
2. Antioxidant and Anti-Inflammatory Protection
DHM possesses strong antioxidant properties that help neutralize reactive oxygen species (ROS) generated by environmental stressors like UV exposure and pollution. When applied topically, DHM can:
- Prevent lipid peroxidation and protect cell membranes
- Support the skin’s natural antioxidant enzyme systems
- Reduce inflammation by modulating key signaling pathways (e.g., NF-κB)
By decreasing oxidative stress and inflammation, DHM may help slow skin aging and reduce photodamage.
3. Photoprotection and Skin Barrier Support
DHM’s ability to counteract oxidative stress and inflammation suggests it may provide protective benefits against UV-induced skin damage. Topical application may help:
- Preserve collagen and elastin integrity
- Maintain overall skin barrier function
- Mitigate signs of photoaging, such as fine lines and hyperpigmentation
These properties make DHM a promising ingredient for sunscreens and anti-aging skincare formulations.
4. Wound Healing and Skin Repair
Preclinical studies have explored DHM’s potential in topical formulations, particularly in wound healing. Research using DHM-loaded nanoparticles has demonstrated enhanced healing of diabetic wounds in animal models. This effect is likely due to DHM’s combined antioxidant, anti-inflammatory, and regenerative properties, making it a candidate for skin repair formulations.
5. Potential Depigmenting Effects
Some studies suggest that DHM may inhibit tyrosinase activity, a key enzyme in melanin synthesis. This indicates potential benefits in reducing hyperpigmentation and evening out skin tone. However, further research is needed to confirm and optimize this application in skincare.
Supporting Research
- Epigenetic Rejuvenation: A study published in Frontiers in Aging demonstrated that DHM inhibits DNMT1 activity in primary human keratinocytes, leading to global hypomethylation and a reduction in the biological age of skin cells.
- Broad Pharmacological Effects: A review in Frontiers in Pharmacology (2018) summarized DHM’s protective effects, including anti-inflammatory, antioxidant, and dermatoprotective activities, highlighting its potential for skincare applications.
- Wound Healing Applications: Research on nanoparticle-mediated delivery of DHM has shown enhanced healing in diabetic wound models, supporting its use in skin repair formulations.
DHM’s diverse biological activities make it a compelling ingredient for future skincare innovations, particularly in anti-aging, photoprotection, and skin regeneration applications.
Usage: Can be used in any anti-aging cosmetics
Mixing method: Dissolves with water part, avoid heat
Usage rate: 0.1-5%
Product characteristics: White-light colored liquid
Solubility: Soluble in water.
Storage: If you want to keep it for the long term Store in the refrigerator. Avoid exposure to light or heat. Seal the lid tightly. Shelf life is at least 2 years.
INCI Name : Propylene Glycol, Polysorbate 80, Dihydromyricetin, Tocopheryl Acetate, Phenoxyethanol, Chlorphenesin
