a naturally occurring polyphenol found in many plants (including coffee beans, fruits, and vegetables) that has attracted attention for its potential skin‐protective benefits when applied topically. the findings suggest several possible benefits for skin care
Caffeic acid is a naturally occurring polyphenol found in many plants (including coffee beans, fruits, and vegetables) that has attracted attention for its potential skin‐protective benefits when applied topically. the findings suggest several possible benefits for skin care. Below is an overview of these benefits along with examples of research citations.
Key Topical Benefits and Mechanisms
1. Antioxidant Activity
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What It Does:
Caffeic acid is a strong antioxidant. It scavenges free radicals and reactive oxygen species (ROS) generated by ultraviolet (UV) exposure and environmental stressors. This helps to minimize oxidative damage to skin cells, which is a key contributor to premature aging and skin damage.
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Research Insight:
In vitro studies have demonstrated that caffeic acid and its derivatives can protect skin cells from oxidative stress. This antioxidative mechanism is thought to underpin many of its other benefits.
2. Anti-Inflammatory Effects
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What It Does:
Caffeic acid can inhibit the production of inflammatory mediators (such as cytokines and prostaglandins) by modulating signaling pathways (for example, by suppressing nuclear factor kappa B, NF‑κB). This may reduce skin inflammation and irritation following environmental insults such as UV exposure.
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Research Insight:
Several studies (often with CAPE as the test agent) have shown reduced markers of inflammation in skin models following topical application.
3. Photoprotective Properties
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What It Does:
By reducing oxidative stress and inflammation, caffeic acid may help protect the skin from UV-induced damage. Additionally, its ability to inhibit enzymes that break down collagen (such as matrix metalloproteinases, MMPs) can contribute to maintaining skin structure.
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Research Insight:
Animal studies have found that topical formulations containing caffeic acid derivatives can reduce UV-induced skin damage and inflammation.
4. Matrix Protection and Anti-Aging
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What It Does:
Inhibition of MMPs helps protect the collagen matrix, which is essential for maintaining skin firmness and reducing wrinkle formation.
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Research Insight:
Studies in cultured human skin fibroblasts have shown that caffeic acid derivatives can reduce the UV-induced expression of MMPs, suggesting a role in anti-aging skin care.
| Benefit |
Description |
Research Paper |
| Antioxidant Activity |
Caffeic acid scavenges free radicals and reactive oxygen species (ROS), reducing oxidative stress and preventing premature aging. |
Kwon, B., et al. (2005).
Caffeic acid phenethyl ester inhibits UVB-induced COX-2 expression by suppressing NF-κB activation in human keratinocytes.
Journal of Investigative Dermatology, 125(1), 177–185. |
| Anti-Inflammatory Effects |
Suppresses NF-κB activation and inhibits inflammatory cytokines, reducing skin redness, irritation, and sensitivity. |
Kwon, B., et al. (2005).
Caffeic acid phenethyl ester inhibits UVB-induced COX-2 expression by suppressing NF-κB activation in human keratinocytes.
Journal of Investigative Dermatology, 125(1), 177–185. |
| Photoprotective Properties |
Protects skin from UV-induced damage by reducing oxidative stress, inflammation, and collagen degradation. |
Lee, J., et al. (2009).
Topical application of caffeic acid phenethyl ester prevents UV-induced skin damage in hairless mice.
Photodermatology, Photoimmunology & Photomedicine, 25(2), 87–92. |
| Matrix Protection and Anti-Aging |
Reduces MMP-1 enzyme activity, preventing collagen breakdown and reducing wrinkle formation. |
Chiu, H.-F., et al. (2009).
Inhibitory effects of caffeic acid derivatives on UV-induced matrix metalloproteinase-1 expression in human dermal fibroblasts.
Journal of Dermatological Science, 54(2), 118–127. |
Usage: For all kinds of cosmetics.
Mixing method: dissolve in water
Usage rate: 0.1-5%
Product characteristics: Light yellow liquid
Solubility: Can be dissolved in water
Storage: For long-term storage Store in the refrigerator. Avoid sunlight and heat. At least 2 years old
INCI Name : PEG8, PEG-40 Hydrogenated Castor Oil, Caffeic acid, Phenoxyethanol, Chlorphenesin, Tocopheryl Acetate
