Cleome Gynandra Leaf Extract (e.q. Pixalia)
Cleome Gynandra Leaf Extract contains high amount of Rutin and Hydroxycinnamic Acid.
Our Cleome Gynandra Leaf Extract contains at least 5,000ppm Rutin and 20,000ppm Hydroxycinnamic Acids
Rutin—a bioflavonoid—and hydroxycinnamic acids (a class of phenolic acids that includes compounds such as caffeic, ferulic, and p‐coumaric acids) have attracted attention in dermatology for their ability to protect and improve skin health. When applied topically, they may offer several benefits:
1. Antioxidant Protection
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Rutin:
Acts as a potent free‐radical scavenger. Its antioxidant properties help neutralize reactive oxygen species (ROS) generated by UV exposure and environmental stress, which can lead to oxidative damage and premature aging.
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Hydroxycinnamic Acids:
Similarly, these compounds intercept free radicals and reduce lipid peroxidation in skin cells, preserving cellular integrity and function.
Research Insight:
Review articles have highlighted the robust antioxidant activity of flavonoids like rutin (Pietta, 2000 ) and phenolic compounds in general (Rice‐Evans et al., 1997 ). These properties are key to counteracting the oxidative stress that contributes to skin aging.
2. Anti-inflammatory Effects
- Mechanism:
Both rutin and hydroxycinnamic acids modulate inflammatory pathways in the skin. They can reduce the release of pro-inflammatory cytokines, which helps calm irritation and mitigate redness.
Research Insight:
Studies indicate that flavonoids can downregulate inflammatory mediators in skin cells, suggesting their utility in reducing inflammation (Balentine et al., 1997 ). Similar anti-inflammatory effects have been observed with hydroxycinnamic acids in preclinical models.
3. Photoprotection
- UV Defense:
Topically applied rutin has been shown in in vitro studies to reduce UVB-induced damage, including DNA lesions and the activation of pathways leading to photoaging. Hydroxycinnamic acids, by virtue of their chemical structure, can absorb portions of the UV spectrum, thereby lessening the amount of UV radiation that reaches deeper skin layers.
Research Insight:
Research on antioxidants in skin care has demonstrated that compounds such as rutin can mitigate UV-induced oxidative stress (Tsuchiya et al., 2013 ). Although research on hydroxycinnamic acids in topical formulations is still evolving, their UV-absorbing capabilities are well recognized.
4. Collagen Preservation and Anti-Aging
- Matrix Protection:
Oxidative stress and inflammation trigger the upregulation of matrix metalloproteinases (MMPs), enzymes that degrade collagen and elastin fibers. Both rutin and hydroxycinnamic acids may inhibit MMP activity, thus helping to preserve the skin’s structural proteins.
Research Insight:
Inhibition of MMPs by antioxidants is a documented mechanism by which skin integrity is maintained, thereby reducing wrinkle formation and loss of elasticity (Tsuchiya et al., 2013 ).
5. Synergistic Benefits
- Combined Efficacy:
When formulated together, the complementary actions of rutin and hydroxycinnamic acids could offer enhanced protection by providing a broader spectrum of antioxidant and anti-inflammatory effects. This synergy may translate into improved skin barrier function and greater overall photoprotection.
Note: While preclinical studies are promising, further clinical research is needed to optimize formulation concentrations and fully establish the efficacy and safety of these compounds in human subjects.
Conclusion
The topical application of rutin combined with hydroxycinnamic acids presents a multifaceted approach to skin care by:
- Scavenging damaging free radicals,
- Reducing inflammation,
- Absorbing UV radiation,
- Inhibiting collagen-degrading enzymes, and
- Potentially working synergistically for enhanced skin protection.
Use: main ingredient in any product To help nourish aging skin, aging skin
How to mix: mix in water
Utilization rate: 0.1-3.0%
Product characteristics: light brown liquid
Solubility: Soluble in water
Storage: Valid for 24 months, please store in the refrigerator at 6 °C -8 °C
INCI Name : Propanediol, Water, Cleome Gynandra Leaf Extract
Minimum 0.5% Rutin and 2% Hydroxycinnamic Acids
