Terrein (NSC 291308) is a natural metabolite derived from fungi, such as Aspergillus terreus, and has shown potential in various biomedical and other applications due to its biological activities. It possesses anti-inflammatory properties, making it a candidate for developing treatments for inflammatory diseases. Additionally, Terrein exhibits antimicrobial effects, which could be useful in combating bacterial and fungal infections. Its antioxidant activity further supports its therapeutic potential. Research has also explored its role in inhibiting melanin production, suggesting applications in skincare for conditions like hyperpigmentation. Furthermore, its ability to inhibit cancer cell growth and modulate cell signaling pathways has sparked interest in its potential use in cancer therapy, particularly in targeting specific cancer cell mechanisms. In agriculture, Terrein may serve as a biopesticide or plant growth regulator.