Berberine sulfate hydrate is widely used in traditional and modern medicine for its antimicrobial and anti-inflammatory properties. It is commonly applied to treat gastrointestinal infections, such as bacterial diarrhea and dysentery, due to its ability to inhibit the growth of harmful bacteria. Additionally, it is utilized in managing conditions like diabetes, as it helps regulate blood sugar levels by improving insulin sensitivity and reducing glucose absorption in the intestines. In dermatology, it is incorporated into topical formulations to address skin infections and inflammation. Its potential in cardiovascular health is also being explored, as it may help lower cholesterol and blood lipid levels, thereby supporting heart function and reducing the risk of cardiovascular diseases. Furthermore, berberine sulfate hydrate is studied for its role in weight management and metabolic syndrome due to its impact on fat metabolism.