Bergaptol is a naturally occurring furanocoumarin found in plants such as bergamot and other citrus species. It is primarily used in dermatology as a photosensitizer in photochemotherapy (PUVA therapy) for treating skin conditions like vitiligo and psoriasis, where it helps stimulate melanin production and repigmentation when combined with UVA light. It has also been investigated for its potential in managing hyperpigmentation by modulating melanogenesis. Research highlights its anti-inflammatory and antioxidant properties, positioning it as a candidate for cosmeceutical formulations to combat oxidative stress and inflammation in skin disorders. Preliminary studies suggest cytotoxic effects against skin cancer cells, though further research is needed to confirm efficacy and safety. Its traditional use in herbal medicine for skin ailments supports its role in modern therapeutic applications, but caution is required due to its photosensitizing effects that can increase UV sensitivity.