Comanthosid B is primarily studied for its potential anti-inflammatory and immunomodulatory effects. It has shown activity in inhibiting key inflammatory mediators, making it a candidate for research in chronic inflammatory diseases. Due to its natural origin and structural complexity, it is also of interest in the development of novel therapeutics targeting immune system regulation. Studies suggest it may influence cellular signaling pathways involved in inflammation and cell survival, particularly through modulation of NF-κB and MAPK pathways. Its application remains mostly in the preclinical research phase, focusing on pharmacological mechanisms and potential use in treating autoimmune conditions or inflammatory disorders.