Chlorantholide D exhibits significant anti-inflammatory activity by inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6 in lipopolysaccharide-stimulated macrophages. It has been studied for its potential in modulating immune responses, particularly in models of acute inflammation. The compound also demonstrates moderate cytotoxic effects against certain human cancer cell lines, suggesting possible utility in anticancer research. Its natural origin and structural complexity make it a candidate for further investigation in drug discovery, especially for inflammation-related disorders and oncology.