The AMG 487 S-enantiomer is primarily investigated for its potential therapeutic applications in the field of immunology and inflammatory diseases. It functions as a selective antagonist of the CXCR3 receptor, which plays a crucial role in the migration of immune cells to sites of inflammation. By blocking this receptor, it may help reduce inflammatory responses and tissue damage in conditions such as autoimmune diseases, psoriasis, and rheumatoid arthritis. Additionally, its application is being explored in the context of organ transplantation to potentially mitigate graft rejection by modulating immune cell trafficking. Research is ongoing to further understand its efficacy and safety in clinical settings.