(-)-Ibuprofenamide is primarily utilized in pharmaceutical research as a chiral intermediate for the synthesis of enantiomerically pure ibuprofen, a widely used nonsteroidal anti-inflammatory drug (NSAID). Its application is crucial in developing formulations with improved efficacy and reduced side effects, as the (-)-enantiomer of ibuprofen is known to exhibit higher biological activity compared to its (+)-counterpart. Additionally, it serves as a valuable compound in studying the stereoselective metabolism and pharmacokinetics of ibuprofen, aiding in the design of more targeted and efficient therapeutic agents.