Glucocorticoid resistance inhibitors are primarily used in medical treatments to enhance the effectiveness of glucocorticoid therapy. Patients with conditions like asthma, chronic obstructive pulmonary disease (COPD), and certain inflammatory or autoimmune diseases often develop resistance to glucocorticoids, reducing the efficacy of these treatments. By inhibiting this resistance, these compounds help restore the therapeutic benefits of glucocorticoids, allowing for better management of symptoms and improved patient outcomes. Additionally, they are being researched for their potential in treating conditions where glucocorticoid signaling is impaired, offering new avenues for addressing complex medical challenges.