Sulindac sulfide is primarily utilized in medical research and pharmaceutical applications due to its anti-inflammatory and anti-cancer properties. It is a metabolite of sulindac, a nonsteroidal anti-inflammatory drug (NSAID), and has been studied for its potential to inhibit the growth of certain cancer cells, particularly in colon and prostate cancers. Researchers are exploring its role in inducing apoptosis (programmed cell death) and reducing tumor progression. Additionally, it is investigated for its ability to modulate signaling pathways involved in inflammation and cell proliferation. While not directly used in clinical treatments, its mechanisms provide valuable insights for developing novel therapeutic strategies.