Glafenine hydrochloride is primarily used as a non-narcotic analgesic and anti-inflammatory agent. It is effective in managing mild to moderate pain, such as headaches, dental pain, and musculoskeletal discomfort. Its anti-inflammatory properties make it suitable for treating conditions like arthritis and other inflammatory disorders. Additionally, it is sometimes employed to alleviate post-operative pain and discomfort associated with minor injuries. Due to its rapid onset of action, it is often preferred for short-term pain relief. However, its use has declined in some regions due to concerns about potential side effects.