Used in dermatological and cosmetic formulations for enhanced skin hydration and moisture retention. The modified hyaluronic acid derivative improves stability and prolongs residence time on the skin, making it effective in anti-aging creams, serums, and moisturizers. Its increased lipophilicity due to the hydrazide modification allows better interaction with skin lipids, supporting improved barrier function and dermal penetration. Commonly found in products targeting fine lines, dryness, and loss of elasticity. Also explored in transdermal drug delivery systems for controlled release of active ingredients.