Sodium 1-hexadecanesulfonate is primarily used as a surfactant in various industrial and household applications. It is effective in reducing surface tension, making it a key component in detergents and cleaning agents. Its ability to emulsify oils and dirt allows it to be used in laundry detergents, dishwashing liquids, and all-purpose cleaners.

In the textile industry, it is employed as a wetting agent and detergent in the processing of fabrics, ensuring even dye distribution and thorough cleaning. It also finds use in the formulation of personal care products like shampoos and body washes, where it aids in the removal of oils and impurities from the skin and hair.

Additionally, it is utilized in the petroleum industry as a component in enhanced oil recovery processes, where it helps to mobilize trapped oil in reservoirs. Its surfactant properties also make it suitable for use in agricultural formulations, such as herbicides and pesticides, to improve the spread and adherence of active ingredients on plant surfaces.