4-Chloro-(N-Boc)aniline

97%

Reagent Code: #162672
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CAS Number 18437-66-6

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 227.69 g/mol
Formula C₁₁H₁₄ClNO₂
badge Registry Numbers
MDL Number MFCD00816772
thermostat Physical Properties
Melting Point 102-106 °C(lit.)
Boiling Point 265.2 °C at 760 mmHg
inventory_2 Storage & Handling
Density 1.195 g/cm3
Storage Room temperature

description Product Description

Widely used in organic synthesis, particularly in pharmaceutical and agrochemical industries, as a protected aniline derivative. The Boc (tert-butoxycarbonyl) group provides stability and selectivity during multi-step reactions by preventing unwanted side reactions at the amine site. The presence of the chlorine substituent allows for further functionalization through cross-coupling reactions such as Suzuki, Heck, or Buchwald-Hartwig aminations. Commonly employed as an intermediate in the preparation of active pharmaceutical ingredients (APIs), where controlled deprotection of the Boc group enables the formation of secondary or tertiary amines. Its balanced reactivity and ease of purification make it a preferred building block in medicinal chemistry and process development.

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 100g
10-20 days ฿3,160.00
inventory 500g
10-20 days ฿14,610.00
inventory 25g
10-20 days ฿1,150.00

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