Used in the synthesis of resins and polymers due to its reactive anhydride group, itaconic anhydride is valuable in creating water-soluble polymers and copolymers for coatings, adhesives, and textile treatments. It serves as a crosslinking agent in polymer systems, improving thermal and mechanical properties. In biomedical applications, it is employed to modify proteins and drugs for targeted delivery due to its ability to form stable amide bonds. It also finds use in developing biodegradable polymers, contributing to environmentally friendly materials. Additionally, it is applied in the production of synthetic lubricants and corrosion inhibitors.