5-(m-Tolyl)-1H-tetrazole
98%
Reagent
Code: #242582
CAS Number
3441-00-7
blur_circular Chemical Specifications
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Molecular Information
Weight
160.18 g/mol
Formula
C₈H₈N₄
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Registry Numbers
MDL Number
MFCD03093096
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as losartan, valsartan, and irbesartan. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the angiotensin II receptor while improving metabolic stability and oral bioavailability. Commonly employed in pharmaceutical research and development for constructing bioisosteres in drug design. Also utilized in coordination chemistry as a ligand for metal ions due to its nitrogen-rich structure.
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