4-(5-trifluoromethyl-tetrazol-1-yl)-phenol
95%
Reagent
Code: #239010
CAS Number
168267-75-2
blur_circular Chemical Specifications
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Molecular Information
Weight
230.149 g/mol
Formula
C₈H₅F₃N₄O
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Registry Numbers
MDL Number
MFCD03093603
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and losartan. Its tetrazole ring mimics the carboxylic acid group in peptides, enhancing metabolic stability and bioavailability. The phenolic hydroxyl group allows for further chemical modification, enabling the construction of complex drug molecules. Widely employed in pharmaceutical research and development for cardiovascular medications.
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