(R)-Methyl 5-(6-(Pivaloyloxymethyl)-1H-Benzo[D]Imidazol-1-Yl)-3-(1-(2-(Trifluoromethyl)Phenyl)Ethoxy)Thiophene-2-Carboxylate
98%
Reagent
Code: #231581
CAS Number
929095-38-5
blur_circular Chemical Specifications
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Molecular Information
Weight
560.58 g/mol
Formula
C₂₈H₂₇F₃N₂O₅S
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Storage & Handling
Storage
2-8°C
description Product Description
Used as an intermediate in the synthesis of angiotensin II receptor antagonists for the treatment of hypertension. Shows high efficacy in blocking the AT1 receptor subtype, contributing to reduced blood pressure. Its structure allows for improved metabolic stability and oral bioavailability in pharmaceutical formulations. Employed in the development of prodrugs due to the presence of ester and pivaloyloxymethyl groups, which enhance intestinal absorption and facilitate in vivo hydrolysis to the active form. Also investigated for use in combination therapies targeting cardiovascular diseases.
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