5-[2-(4-Methylbiphenyl)]Tetrazole
98%
Reagent
Code: #212746
CAS Number
120568-11-8
science Other reagents with same CAS 120568-11-8
blur_circular Chemical Specifications
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Molecular Information
Weight
236.27 g/mol
Formula
C₁₄H₁₂N₄
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Storage & Handling
Storage
Room temperature
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of antihypertensive drugs like candesartan and related sartan-class medications. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the angiotensin II receptor. This compound plays a critical role in improving the potency and metabolic stability of these drugs. It is also employed in medicinal chemistry research for developing new bioactive molecules due to its favorable pharmacokinetic properties and ability to increase water solubility of drug candidates.
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