5-(2′-methoxy-[1,1′-biphenyl]-3-yl)-1H-tetrazole
97%
Reagent
Code: #193134
CAS Number
1956331-43-3
science Other reagents with same CAS 1956331-43-3
blur_circular Chemical Specifications
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Molecular Information
Weight
252.275 g/mol
Formula
C₁₄H₁₂N₄O
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of antihypertensive drugs like valsartan and related sartan-class medications. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the AT1 receptor. This compound plays a critical role in improving the potency and metabolic stability of these drugs. It is also employed in medicinal chemistry research for developing new cardiovascular therapeutics.
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