1H-Tetrazole, 5-(ethylsulfonyl)-1-phenyl-

≥95%

Reagent Code: #191973
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CAS Number 3206-46-0

science Other reagents with same CAS 3206-46-0

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 238.2663 g/mol
Formula C₉H₁₀N₄O₂S
badge Registry Numbers
MDL Number MFCD00447901
thermostat Physical Properties
Melting Point 73-74 °C
Boiling Point 435.3±28.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.44±0.1 g/cm3(Predicted)
Storage 2-8°C

description Product Description

Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and irbesartan. The tetrazole ring with the ethylsulfonyl and phenyl substituents enhances metabolic stability and binding affinity to the AT1 receptor. It is also employed in medicinal chemistry for developing bioisosteres of carboxylic acids due to the tetrazole group’s ability to mimic carboxylate anions while improving lipophilicity and oral bioavailability. Additionally, this compound finds use in the preparation of agrochemicals and functional materials where nitrogen-rich heterocycles are required for activity or structural properties.

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Size Availability Unit Price Quantity
inventory 10mg
10-20 days ฿1,600.00

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1H-Tetrazole, 5-(ethylsulfonyl)-1-phenyl-
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Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and irbesartan. The tetrazole ring with the ethylsulfonyl and phenyl substituents enhances metabolic stability and binding affinity to the AT1 receptor. It is also employed in medicinal chemistry for developing bioisosteres of carboxylic acids due to the tetrazole group’s ability to mimic carboxylate anions while improving lipophilicity and oral bioavailability. Additionally, this compound finds use in the preparation of agrochemicals and functional materials where nitrogen-rich heterocycles are required for activity or structural properties.
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