1H-Tetrazole, 5-(ethylsulfonyl)-1-phenyl-
≥95%
Reagent
Code: #191973
CAS Number
3206-46-0
science Other reagents with same CAS 3206-46-0
blur_circular Chemical Specifications
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Molecular Information
Weight
238.2663 g/mol
Formula
C₉H₁₀N₄O₂S
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Registry Numbers
MDL Number
MFCD00447901
thermostat
Physical Properties
Melting Point
73-74 °C
Boiling Point
435.3±28.0 °C(Predicted)
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Storage & Handling
Density
1.44±0.1 g/cm3(Predicted)
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and irbesartan. The tetrazole ring with the ethylsulfonyl and phenyl substituents enhances metabolic stability and binding affinity to the AT1 receptor. It is also employed in medicinal chemistry for developing bioisosteres of carboxylic acids due to the tetrazole group’s ability to mimic carboxylate anions while improving lipophilicity and oral bioavailability. Additionally, this compound finds use in the preparation of agrochemicals and functional materials where nitrogen-rich heterocycles are required for activity or structural properties.
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