(2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methanol

97%

Reagent Code: #191208
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CAS Number 160514-13-6

science Other reagents with same CAS 160514-13-6

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 252.27 g/mol
Formula C₁₄H₁₂N₄O
badge Registry Numbers
MDL Number MFCD29920703
thermostat Physical Properties
Boiling Point 527.6±60.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.315±0.06 g/cm3(Predicted)
Storage 2-8°C, Inert Gas

description Product Description

Used primarily as an intermediate in the synthesis of angiotensin II receptor antagonists, such as valsartan and related sartan-class antihypertensive drugs. Its tetrazole group mimics the carboxylate group in angiotensin II, enabling effective binding to the AT1 receptor. The biphenyl methanol structure provides a rigid scaffold that enhances selectivity and potency. It is valuable in pharmaceutical development for creating potent, orally active agents that lower blood pressure by blocking vasoconstriction and aldosterone release.

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Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿6,010.00
inventory 1g
10-20 days ฿27,510.00

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(2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methanol
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Used primarily as an intermediate in the synthesis of angiotensin II receptor antagonists, such as valsartan and related sartan-class antihypertensive drugs. Its tetrazole group mimics the carboxylate group in angiotensin II, enabling effective binding to the AT1 receptor. The biphenyl methanol structure provides a rigid scaffold that enhances selectivity and potency. It is valuable in pharmaceutical development for creating potent, orally active agents that lower blood pressure by blocking vasoconstriction and aldosterone release.
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