(2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methanol
97%
Reagent
Code: #191208
CAS Number
160514-13-6
science Other reagents with same CAS 160514-13-6
blur_circular Chemical Specifications
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Molecular Information
Weight
252.27 g/mol
Formula
C₁₄H₁₂N₄O
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Registry Numbers
MDL Number
MFCD29920703
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Physical Properties
Boiling Point
527.6±60.0 °C(Predicted)
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Storage & Handling
Density
1.315±0.06 g/cm3(Predicted)
Storage
2-8°C, Inert Gas
description Product Description
Used primarily as an intermediate in the synthesis of angiotensin II receptor antagonists, such as valsartan and related sartan-class antihypertensive drugs. Its tetrazole group mimics the carboxylate group in angiotensin II, enabling effective binding to the AT1 receptor. The biphenyl methanol structure provides a rigid scaffold that enhances selectivity and potency. It is valuable in pharmaceutical development for creating potent, orally active agents that lower blood pressure by blocking vasoconstriction and aldosterone release.
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