5-(2,5-Dichlorophenyl)-1H-tetrazole
≧95%
Reagent
Code: #177129
CAS Number
98555-71-6
blur_circular Chemical Specifications
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Molecular Information
Weight
215.04 g/mol
Formula
C₇H₄Cl₂N₄
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Registry Numbers
MDL Number
MFCD02093954
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Physical Properties
Melting Point
155-158 °C
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and losartan. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the angiotensin II receptor. Due to this property, it plays a crucial role in improving the potency and oral bioavailability of these medications. Also employed in coordination chemistry as a ligand for metal ions, forming stable complexes with potential applications in catalysis and material science.
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