5-[2-(Cbz-amino)ethyl]-1H-tetrazole
≥95%
Reagent
Code: #173776
CAS Number
33841-54-2
blur_circular Chemical Specifications
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Molecular Information
Weight
247.25 g/mol
Formula
C₁₁H₁₃N₅O₂
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Registry Numbers
MDL Number
MFCD22574988
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the preparation of sartan-class antihypertensive drugs such as valsartan and losartan. The tetrazole ring mimics the carboxylic acid group in biological activity, enhancing binding to the angiotensin II receptor. The Cbz-protected amine allows for selective deprotection and further coupling in multi-step syntheses, making it valuable in pharmaceutical development for cardiovascular medications.
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