5-[4-(Methylsulfonyl)phenyl]-2H-tetrazole
95%
Reagent
Code: #173769
CAS Number
441054-54-2
blur_circular Chemical Specifications
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Molecular Information
Weight
224.24 g/mol
Formula
C₈H₈N₄O₂S
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Registry Numbers
MDL Number
MFCD07432784
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of antihypertensive drugs like valsartan and related sartan-class medications. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the angiotensin II receptor. Due to its polarity and metabolic stability, it improves the pharmacokinetic profile of the final drug product. Also employed in medicinal chemistry research for developing new bioactive molecules where tetrazole functionality is required for activity.
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