ZM323881 is primarily utilized in research settings to study cellular signaling pathways. It acts as a selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), which plays a critical role in angiogenesis, the process of new blood vessel formation. By inhibiting VEGFR-2, ZM323881 helps researchers understand the mechanisms of angiogenesis and its implications in diseases such as cancer, where abnormal blood vessel growth supports tumor development. This compound is also used in preclinical studies to evaluate potential anti-angiogenic therapies, providing insights into its efficacy in blocking tumor progression. Additionally, ZM323881 serves as a valuable tool in exploring the broader role of VEGFR-2 in other physiological and pathological processes, such as wound healing and inflammatory conditions.