Ammonium formate is widely used as a buffering agent in liquid chromatography, particularly in mass spectrometry, to improve the separation and detection of analytes. It serves as a mobile phase additive, enhancing ionization efficiency and providing stable pH conditions. In organic synthesis, it acts as a reducing agent and a source of formate ions in catalytic hydrogenation reactions. Additionally, it is employed in the preparation of formic acid and as a nitrogen source in biochemical processes. Its role in the synthesis of pharmaceuticals and agrochemicals is also notable due to its compatibility with various reaction conditions.