Trifluoroacetic acid (TFA)
for HPLC, ≥99.5%
Reagent
Code: #93269
Alias
Trifluoroacetic acid
CAS Number
76-05-1
science Other reagents with same CAS 76-05-1
blur_circular Chemical Specifications
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Molecular Information
Weight
114.02 g/mol
Formula
C₂HO₂F₃
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Registry Numbers
EC Number
200-929-3
MDL Number
MFCD00004169
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Physical Properties
Melting Point
-15 °C
Boiling Point
72.4 °C(lit.)
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Storage & Handling
Density
1.489 g/mL at 20 °C(lit.)
Storage
room temperature
description Product Description
Trifluoroacetic acid (TFA) is widely used in organic synthesis as a strong acid catalyst for various reactions, including esterifications, acylations, and deprotections. It is particularly valued in peptide synthesis for removing protecting groups like t-butyl and benzyl, ensuring high yields and purity. In the pharmaceutical industry, TFA is employed in the purification and analysis of compounds, often as a mobile phase additive in HPLC to improve separation efficiency. Additionally, TFA serves as a solvent for highly polar substances and is utilized in the production of polymers, dyes, and agricultural chemicals. Its strong acidity and volatility make it a versatile reagent in both laboratory and industrial settings.
format_list_bulleted Product Specification
| Test Parameter | Specification |
|---|---|
| UV Absorption (260 nm) | 0-0.9 |
| 270 nm | 0-0.1 |
| 280 nm | 0-0.05 |
| 290 nm | 0.04 |
| 300 nm | 0-0.03 |
| 320 nm | 0-0.025 |
| Water (Karl Fischer) | <=0.05% |
| Appearance | Colorless liquid |
| Refractive Index (n20D) | 1.2830-1.2870 |
| Purity | 99.5-100 |
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