Sodium tert-pentoxide is primarily used as a strong base in organic synthesis. It is particularly effective in deprotonation reactions, where it facilitates the removal of protons from weakly acidic compounds, enabling the formation of carbanions. This reactivity makes it valuable in the preparation of complex organic molecules, including pharmaceuticals and fine chemicals. Additionally, it serves as a catalyst or reagent in polymerization processes, aiding in the production of certain types of polymers. Its strong basicity also makes it useful in the synthesis of specialty chemicals and intermediates, where precise control over reaction conditions is required.