Potassium tert-butoxide is widely used as a strong base in organic synthesis, particularly in deprotonation reactions. It is commonly employed in the preparation of esters, ethers, and other organic compounds where a non-nucleophilic base is required. In the pharmaceutical industry, it plays a key role in the synthesis of active pharmaceutical ingredients (APIs) by facilitating reactions like eliminations and substitutions. Additionally, it is utilized in polymer chemistry as a catalyst for the polymerization of certain monomers. Its strong basicity and solubility in organic solvents make it a valuable reagent in various industrial and laboratory applications.