Sodium tert-butoxide is widely used as a strong base in organic synthesis, particularly in deprotonation reactions. It is commonly employed in the formation of carbon-carbon bonds, such as in aldol condensations and alkylation reactions. Its steric bulk makes it effective in promoting elimination reactions, like the E2 mechanism, where it helps in the formation of alkenes from alkyl halides. Additionally, it serves as a catalyst or reagent in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. Its ability to generate highly reactive intermediates makes it valuable in polymerization processes, especially in the production of specialty polymers. Due to its strong basicity, it is also used in the preparation of metal-organic frameworks (MOFs) and other advanced materials.