1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) is widely used as a strong, non-nucleophilic base in organic synthesis. It is particularly effective in deprotonation reactions, where it facilitates the formation of carbanions or enolates from weakly acidic compounds. This makes it valuable in reactions such as alkylations, condensations, and polymerizations.

DBN is also employed in the production of polyurethanes, where it acts as a catalyst for the reaction between isocyanates and polyols, ensuring efficient curing and foam formation. Additionally, it is utilized in the synthesis of pharmaceuticals and fine chemicals, where its ability to promote selective reactions under mild conditions is advantageous.

In polymer chemistry, DBN is used to catalyze the ring-opening polymerization of cyclic esters and carbonates, leading to the production of biodegradable plastics. Its versatility and effectiveness in various chemical processes make it a key reagent in industrial and research applications.