Tetramethylammonium hydroxide solution is widely used in the electronics industry as a developer in the photolithography process for manufacturing semiconductors and integrated circuits. It helps in creating precise patterns on silicon wafers by removing exposed photoresist layers, ensuring high-resolution microstructures.

In analytical chemistry, it serves as an ion-pairing reagent in liquid chromatography, enhancing the separation of complex mixtures. Additionally, it is utilized in the synthesis of organic compounds as a strong base or catalyst, particularly in reactions requiring controlled pH conditions.

The solution is also employed in the production of liquid crystal displays (LCDs) as an etchant for indium tin oxide (ITO) layers, contributing to the fabrication of transparent conductive coatings. Its role in these applications underscores its importance in advanced manufacturing and research processes.