Florfenicol is widely used in veterinary medicine as an antibiotic to treat bacterial infections in livestock, poultry, and aquaculture. It is particularly effective against respiratory and systemic infections caused by susceptible organisms. In cattle, it is commonly used to treat bovine respiratory disease (BRD) and foot rot. In pigs, it helps control swine respiratory disease and bacterial enteritis. In aquaculture, florfenicol is administered to treat bacterial infections in fish, such as furunculosis in salmon and columnaris disease in catfish. Its broad-spectrum activity and effectiveness against both gram-positive and gram-negative bacteria make it a valuable tool in managing animal health and ensuring food safety. Proper dosage and adherence to withdrawal periods are essential to minimize the risk of antibiotic resistance and ensure compliance with regulatory standards.