Used primarily in hormone replacement therapy to alleviate symptoms of menopause, such as hot flashes and vaginal dryness, and to prevent osteoporosis. It is also employed in the treatment of hypoestrogenism caused by hypogonadism, primary ovarian failure, or after surgical removal of the ovaries. Additionally, it plays a role in managing certain types of breast cancer and prostate cancer by altering hormone levels in the body. In transgender hormone therapy, it is used to induce feminizing changes. It is also utilized in some contraceptive formulations and in veterinary medicine to regulate reproductive cycles in animals.