Acemetacin is primarily used as a non-steroidal anti-inflammatory drug (NSAID) to treat pain, inflammation, and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is often prescribed for its ability to reduce swelling and improve joint mobility, making it beneficial for patients with chronic inflammatory joint diseases. Additionally, it can be used to manage acute musculoskeletal disorders, such as sprains or strains, by alleviating pain and inflammation. Acemetacin is typically administered orally, and its therapeutic effects are attributed to its inhibition of prostaglandin synthesis, which plays a key role in the inflammatory process. It is important to use this medication under medical supervision due to potential side effects, particularly on the gastrointestinal system.