Used primarily to treat infections caused by liver flukes, especially Fasciola hepatica and Fasciola gigantica, in both humans and animals. It is highly effective against immature and adult stages of the parasite, making it the drug of choice for acute and chronic fascioliasis. Commonly used in veterinary medicine for sheep, cattle, and goats, it helps control parasitic infections that affect liver function and overall productivity. Its ability to penetrate tissue and target parasites in the bile ducts enhances its therapeutic value. Also used off-label for other trematode infections in endemic regions.