Tetrahydrofuran is widely used as a polar aprotic solvent in organic synthesis due to its excellent ability to dissolve a variety of organic and inorganic compounds. It is particularly effective in reactions involving organometallic reagents such as Grignard reagents and lithium aluminum hydride, where its ability to stabilize reactive intermediates is crucial.

It serves as a key solvent in polymer science, especially in the preparation and processing of polymers like polyvinyl chloride (PVC) and polyurethanes. Tetrahydrofuran is also used in the production of adhesives, coatings, and inks because of its good film-forming properties and fast evaporation rate.

In industrial applications, it acts as a reaction medium for the synthesis of fine chemicals and pharmaceuticals. It is commonly used in hydroboration and hydrosilylation reactions. Additionally, tetrahydrofuran is employed in the laboratory for chromatographic techniques and as a mobile phase in HPLC under certain conditions.

Due to its miscibility with water and many organic solvents, it is a versatile choice for extraction and purification processes. However, its tendency to form peroxides upon exposure to air requires careful handling and storage.